Symetrics is a framework that leverages the existing synonymous variant effect measure to generate gene-wise proportion score (Symetrics Z-Score) which aggregates existing synonymous variant effect measures. These scores were also compared to existing gene-wise scores such as pLI and missense z scores. It also has predictive capability to address the need of evaluating the deleteriousness of synonymous variants.

Features	Tools	Metrics	Description
Functional Consequence	Synvep	Synvep Score	Probability of human synonymous variant to have an effect
Splicing Effect	SpliceAI	Max Delta Scores	Derived value from the possible delta scores of the variant
Splicing Effect	Maximum Entropy Score	MES	A score associated with splicing
RNA Stability	SURF	SURF Scores	Measure of how a synonymous mutation affects the stability of RNA
Conservation and Phylogenetic Relevance	SILVA	GERP++	Measure of conservation for a given synonymous mutation
Codon Usage	SILVA	RSCU	Relative synonymous codon usage of new codon
Codon Usage	SILVA	dRSCU	Change in Relative synonymous codon usage caused by mutation
Sequence Properties	SILVA	CpG_exon	Observed/expected CpG content of exon
Sequence Properties	SILVA	CpG	Binary values implying whether a mutation changes a CpG or not
Sequence Properties	SILVA	f_premrna	Relative distance to the end of pre-MRNA
Sequence Properties	SILVA	f_mrna	Relative distance to the end of mature MRNA